Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury

@article{Pot2002NogoAEI,
  title={Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury},
  author={Caroline Pot and Marjo Simonen and Oliver Weinmann and Lisa J. Schnell and Franziska Christ and Sascha Stoeckle and Philipp Berger and Thomas R{\"u}licke and Ueli Suter and Martin E. Schwab},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={159},
  pages={29 - 35}
}
Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired… CONTINUE READING

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