Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

@article{Freund2006NogoAspecificAT,
  title={Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates},
  author={Patrick Freund and Eric Schmidlin and Thierry Wannier and Jocelyne Bloch and Anis Khusro Mir and Martin E. Schwab and Eric M. Rouiller},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={790-792}
}
In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control antibody. NOTE: In the version of this article initially published, the cut corticospinal tract (CST… CONTINUE READING

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