Nogo-66 receptor antagonist peptide promotes axonal regeneration

@article{Grandpr2002Nogo66RA,
  title={Nogo-66 receptor antagonist peptide promotes axonal regeneration},
  author={Tadzia Grandpr{\'e} and Shuxin Li and Stephen M. Strittmatter},
  journal={Nature},
  year={2002},
  volume={417},
  pages={547-551}
}
Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. A 66-residue domain of Nogo (Nogo-66) is expressed on the surface of oligodendrocytes and can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). The IN-1 monoclonal antibody recognizes Nogo-A and promotes corticospinal tract regeneration and locomotor recovery; however, the undefined nature of the IN-1 epitope… 

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo.

NgR is not essential for mediating inhibitory signals from CNS myelin, at least in the neurons tested, whereas p75(NTR) plays a central role in this response.

Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury

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Soluble Nogo Receptor Down-regulates Expression of Neuronal Nogo-A to Enhance Axonal Regeneration*

The results indicate that neuronal Nogo-A is an important intermediate in neurite growth dynamics and its expression is regulated by signals related to axonal injury and regeneration, that CNS myelin appears to activate signaling events that mimicAxonal injury, and that NgSR released from QHNgSR may be used to improve recovery after injury.

The Nogo receptor, its ligands and axonal regeneration in the spinal cord; A review

It is not clear whether antibodies against Nogo act on oligodendrocytes/myelin or by binding to neuronal Nogo, or whether they can stimulate regeneration of ascending axons in the spinal cord, most of which express little or no NgR.

Nogo-C is sufficient to delay nerve regeneration

Inhibition of Retinal Ganglion Cell Axonal Outgrowth Through the Amino-Nogo-A Signaling Pathway

The results suggest that Amino-Nogo inhibits RGC axonal outgrowth primarily through the integrin αv signaling pathway.
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