Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells.

@article{Liao2004Nogo66AM,
  title={Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells.},
  author={Hong Liao and Tetyana Duka and Felicia Yu Hsuan Teng and Li Sun and Wen-yu Bu and Sohail Ahmed and Bor Luen Tang and Zhi-cheng Xiao},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 5},
  pages={1156-62}
}
Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated glycoprotein (MAG). U87MG cells contained significant amounts of endogenous Nogo-66 receptor (NgR), and treatment of the cells with phosphatidylinositol-specific phospholipase C… CONTINUE READING