Noggin is required for induction of the hair follicle growth phase in postnatal skin

@article{Botchkarev2001NogginIR,
  title={Noggin is required for induction of the hair follicle growth phase in postnatal skin},
  author={V. Botchkarev and N. Botchkareva and M. Nakamura and O. Huber and K. Funa and R. Lauster and R. Paus and B. Gilchrest},
  journal={The FASEB Journal},
  year={2001},
  volume={15},
  pages={2205 - 2214}
}
  • V. Botchkarev, N. Botchkareva, +5 authors B. Gilchrest
  • Published 2001
  • Biology, Medicine
  • The FASEB Journal
  • During postnatal development, the hair follicle (HF) shows cyclic activity with periods of relative resting, active growth (anagen), and regression. We demonstrate that similar to the HF induction in embryonic skin, initiation of a new hair growth phase in postnatal skin requires neutralization of the inhibitory activity of bone morphogenetic protein 4 (BMP4) by the BMP antagonist noggin. In the resting HF, BMP4 mRNA predominates over noggin in the epithelium and mesenchyme, and the BMP… CONTINUE READING
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