Noggin is a mesenchymally derived stimulator of hair-follicle induction

  title={Noggin is a mesenchymally derived stimulator of hair-follicle induction},
  author={V. Botchkarev and N. Botchkareva and W. Roth and M. Nakamura and L. Chen and W. Herzog and G. Lindner and J. McMahon and C. Peters and R. Lauster and A. McMahon and R. Paus},
  journal={Nature Cell Biology},
  • V. Botchkarev, N. Botchkareva, +9 authors R. Paus
  • Published 1999
  • Biology, Medicine
  • Nature Cell Biology
  • The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes… CONTINUE READING
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