Noggin is a mesenchymally derived stimulator of hair-follicle induction

@article{Botchkarev1999NogginIA,
  title={Noggin is a mesenchymally derived stimulator of hair-follicle induction},
  author={V. Botchkarev and N. Botchkareva and W. Roth and M. Nakamura and L. Chen and W. Herzog and G. Lindner and J. McMahon and C. Peters and R. Lauster and A. McMahon and R. Paus},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={158-164}
}
  • V. Botchkarev, N. Botchkareva, +9 authors R. Paus
  • Published 1999
  • Biology, Medicine
  • Nature Cell Biology
    • The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    381 Citations
    Highly Influencial Citations
    24
    Background Citations
    168
    Methods Citations
    14
    Results Citations
    5
    381 Citations
    Citation Type

    Citation Type

    Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.
    • 133
    Noggin is required for induction of the hair follicle growth phase in postnatal skin
    • 202
    FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin
    • 38
    Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
    • 253
    Overexpression of Fgf8 in the epidermis inhibits hair follicle development.
    Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    • 237
    • Highly Influenced
    • PDF
    Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
    • 353
    • Highly Influenced
    • PDF
    BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice
    • 86
    • PDF
    Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface.
    • 31
    • PDF
    Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling.
    • 58

    References

    SHOWING 1-10 OF 56 REFERENCES
    Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.
    • 425
    • PDF
    Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.
    • 168
    • PDF
    Sonic hedgehog signaling is essential for hair development
    • 700
    Essential role for Sonic hedgehog during hair follicle morphogenesis.
    • 477
    Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
    • 814
    • PDF
    Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud
    • 89
    Splitting Hairs Dissecting Roles of Signaling Systems in Epidermal Development
    • 151
    Experimental induction of BMP-4 expression leads to apoptosis in the paraxial and lateral plate mesoderm.
    • 41
    De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
    • 1,077
    Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
    • 942
    • PDF