Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis.

@article{Poggio2013NogginAT,
  title={Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis.},
  author={Paolo Poggio and Rachana Sainger and Emanuela Branchetti and Juan B. Grau and Eric K. Lai and Robert C. Gorman and Michael S. Sacks and Alessandro Parolari and Joseph E. Bavaria and Giovanni Ferrari},
  journal={Cardiovascular research},
  year={2013},
  volume={98 3},
  pages={402-10}
}
AIMS Aortic valve sclerosis (AVSc) is a hallmark of several cardiovascular conditions ranging from chronic heart failure and myocardial infarction to calcific aortic valve stenosis (AVS). AVSc, present in 25-30% of patients over 65 years of age, is characterized by thickening of the leaflets with marginal effects on the mechanical proprieties of the valve making its presentation asymptomatic. Despite its clinical prevalence, few studies have investigated the pathogenesis of this disease using… CONTINUE READING
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