Noggin Is a Negative Regulator of Neuronal Differentiation in Developing Neocortex

  title={Noggin Is a Negative Regulator of Neuronal Differentiation in Developing Neocortex},
  author={W. Li and J. Loturco},
  journal={Developmental Neuroscience},
  pages={68 - 73}
  • W. Li, J. Loturco
  • Published 2000
  • Biology, Medicine
  • Developmental Neuroscience
  • Bone morphogenetic proteins (BMPs) trigger neuronal differentiation of neocortical precursors within the ventricular zone (VZ) [Li et al. (1998): J Neurosci 18:8853–8862]. BMP-2/4 protein is concentrated at the VZ surface and BMPs rapidly promote the differentiation of neocortical precursors in both dissociated cell and explant cultures. Noggin binds to BMP-2/4 with high affinity, and prevents binding to cell surface receptors. In the present study, we used human recombinant noggin protein to… CONTINUE READING
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