Noduliprevenone: a novel heterodimeric chromanone with cancer chemopreventive potential.

@article{Pontius2008NoduliprevenoneAN,
  title={Noduliprevenone: a novel heterodimeric chromanone with cancer chemopreventive potential.},
  author={Alexander Pontius and Anja Krick and Stefan Kehraus and Silke E Foegen and Michael M{\"u}ller and Karin Klimo and Clarissa Gerh{\"a}user and Gabriele M K{\"o}nig},
  journal={Chemistry},
  year={2008},
  volume={14 32},
  pages={9860-3}
}
Chemoprevention is considered a new strategy in fighting diverse types of cancer. To influence cancer development and progression, signaling pathways, for example, enzymes like cyclooxygenase-2, transcription factors like NF-kB, and several metabolic processes leading to activation or deactivation of carcinogenic agents, are envisaged as promising approaches. Cytochrome P450 (CYP) enzymes activate xenobiotics and thus contribute to the generation of potent carcinogens. Accordingly, inhibition… CONTINUE READING