Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

  title={Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion},
  author={Michele R. Erickson-Johnson and Margaret M. Chou and Barbara R Evers and Christopher W Roth and Amber R Seys and Long Jin and Ying Ye and Alan C. W. Lau and Xiaoke Wang and Andr{\'e} Luiz Malavasi Longo de Oliveira},
  journal={Laboratory Investigation},
Nodular fasciitis (NF) is a relatively common mass-forming and self-limited subcutaneous pseudosarcomatous myofibroblastic proliferation of unknown pathogenesis. Due to its rapid growth and high mitotic activity, NF is often misdiagnosed as a sarcoma. While studying the USP6 biology in aneurysmal bone cyst and other mesenchymal tumors, we identified high expression levels of USP6 mRNA in two examples of NF. This finding led us to further examine the mechanisms underlying USP6 overexpression in… CONTINUE READING
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