Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact

@article{Vigan2015NodularRH,
  title={Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact},
  author={Luca Vigan{\`o} and Laura A Rubbia-Brandt and Giovanni De Rosa and Pietro Edoardo Majno and Serena Langella and PhD Christian Toso and Gilles Mentha and Lorenzo Capussotti},
  journal={Annals of Surgical Oncology},
  year={2015},
  volume={22},
  pages={4149-4157}
}
Nodular regenerative hyperplasia (NRH) is a severe form of chemotherapy-related liver injury (CALI) that may worsen the short-term outcome of liver resection (LR) for colorectal metastases (CRLM). The present study aimed to clarify the incidence, risk factors, preoperative assessment, and clinical impact of NRH. Overall, 406 patients undergoing 478 LRs for CRLM after chemotherapy between 2000 and 2012 were studied. All resection specimens were reviewed. After Gomori staining, NRH was graded… CONTINUE READING
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