Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.

@article{Chamaillard2003NodsNA,
  title={Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.},
  author={Mathias Chamaillard and Stephen E. Girardin and J{\'e}r{\^o}me Viala and Dana J Philpott},
  journal={Cellular microbiology},
  year={2003},
  volume={5 9},
  pages={581-92}
}
The innate immune system is the most ancestral and ubiquitous system of defence against microbial infection. The microbial sensing proteins involved in innate immunity recognize conserved and often structural components of microorganisms. One class of these pattern-recognition molecules, the Toll-like receptors (TLRs), are involved in detection of microbes in the extracellular compartment whereas a newly discovered family of proteins, the NBS-LRR proteins (for nucleotide-binding site and… CONTINUE READING
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