Node-pore sensing: a robust, high-dynamic range method for detecting biological species.

@article{Balakrishnan2013NodeporeSA,
  title={Node-pore sensing: a robust, high-dynamic range method for detecting biological species.},
  author={Karthik R. Balakrishnan and George Anwar and Matthew R Chapman and Trongtuong Nguyen and Anand Kesavaraju and Lydia L. Sohn},
  journal={Lab on a chip},
  year={2013},
  volume={13 7},
  pages={1302-7}
}
Resistive-pulse sensing (RPS), which is based on measuring the current pulse produced when a single particle transits a pore or channel, is an extremely versatile technique used to determine the size and concentration of cells and viruses and to detect single molecules. A major challenge to RPS is dynamic range: smaller particles in a heterogeneous sample can go undetected because of low signal-to-noise ratios (SNRs) and the fact that the pore size must be commensurate with that of the largest… CONTINUE READING
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