Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei.

@article{Roussign2009NodalSI,
  title={Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei.},
  author={Myriam Roussign{\'e} and Isaac Henry Bianco and Stephen W. Wilson and Patrick Blader},
  journal={Development},
  year={2009},
  volume={136 9},
  pages={1549-57}
}
The habenulae are evolutionarily conserved bilateral nuclei in the epithalamus that relay input from the forebrain to the ventral midbrain. In zebrafish, the habenulae display left-right (L/R) asymmetries in gene expression and axonal projections. The elaboration of habenular asymmetries requires the presence of a second asymmetric structure, the parapineal, the laterality of which is biased by unilateral Nodal signalling. Here we show that neurons are present earlier in the left habenula than… CONTINUE READING