Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.

@article{Kumar2001NodalSU,
  title={Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.},
  author={Anil Kumar and V. P. Novoselov and Anthony J. Celeste and Neil M. Wolfman and Peter Ten Dijke and Michael R. Kuehn},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 1},
  pages={
          656-61
        }
}
Nodal, a member of the transforming growth factor beta (TGF-beta) superfamily, is implicated in many events critical to the early vertebrate embryo, including mesoderm formation, anterior patterning, and left-right axis specification. Here we define the intracellular signaling pathway induced by recombinant nodal protein treatment of P19 embryonal carcinoma cells. Nodal signaling activates pAR3-Lux, a luciferase reporter previously shown to respond specifically to activin and TGF-beta. However… CONTINUE READING
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