Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

@article{Yamamoto2003NodalSI,
  title={Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.},
  author={Masamichi Yamamoto and Naoki Mine and Kyoko Mochida and Yasuo Sakai and Yukio Saijoh and Chikara Meno and Hiroshi Hamada},
  journal={Development},
  year={2003},
  volume={130 9},
  pages={
          1795-804
        }
}
The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or by electroporation of a Nodal vector, induced Nodal expression in wild-type embryos but not in the… CONTINUE READING

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