Nodal proteins are target antigens in Guillain-Barré syndrome.

  title={Nodal proteins are target antigens in Guillain-Barr{\'e} syndrome.},
  author={J{\'e}r{\^o}me J. Devaux and Masaaki Odaka and Nobuhiro Yuki},
  journal={Journal of the peripheral nervous system : JPNS},
  volume={17 1},
Neurofascin-186 (NF186), neuronal cell adhesion molecule (NrCAM), and gliomedin are adhesion molecules playing a central role in the formation of nodes of Ranvier. In Guillain-Barré syndrome (GBS), immune attack toward the nodes may participate in the disabilities. Autoantibodies to NF186 and gliomedin have been detected in a rat model of GBS. Here, we investigated the prevalence of antibodies against nodal adhesion molecules in patients with GBS or chronic inflammatory demyelinating… CONTINUE READING


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