Nodal points and complexity of Notch-Ras signal integration.

  title={Nodal points and complexity of Notch-Ras signal integration.},
  author={Gregory D. Hurlbut and Mark W. Kankel and S. Artavanis-Tsakonas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 7},
Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data supporting a role for selected mutually… CONTINUE READING
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