Nodal morphogens.

  title={Nodal morphogens.},
  author={Alexander F Schier},
  journal={Cold Spring Harbor perspectives in biology},
  volume={1 5},
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by… CONTINUE READING

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