Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.

@article{Fuerer2014NodalGdf1HW,
  title={Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.},
  author={Christophe Fuerer and Maria Cristina Nostro and Daniel B. Constam},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 25},
  pages={
          17854-71
        }
}
The TGFβ family member Nodal is central to control pluripotent stem cell fate, but its use as a stem cell differentiation factor is limited by low specific activity. During development, Nodal depends on growth and differentiation factor (Gdf)-1 and on the shared co-receptor Cryptic to specify visceral left-right axis asymmetry. We therefore asked whether the functionality of Nodal can be augmented by Gdf1. Because Nodal and Gdf1 coimmunoprecipitate each other, they were predicted to form… CONTINUE READING

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