Nodal: master and commander of the dorsal-ventral and left-right axes in the sea urchin embryo.

@article{Molina2013NodalMA,
  title={Nodal: master and commander of the dorsal-ventral and left-right axes in the sea urchin embryo.},
  author={Maria Dolores Molina and No{\'e}mie de Croz{\'e} and Emmanuel Haillot and Thierry Lepage},
  journal={Current opinion in genetics & development},
  year={2013},
  volume={23 4},
  pages={445-53}
}
Recent studies suggest that specification of the dorsal-ventral and left-right axes of the sea urchin embryo relies on Nodal-expressing signalling centres located in the ventral ectoderm and in the archenteron that share striking similarities with vertebrate organising centres. Nodal and its downstream target BMP2/4 pattern all three germ layers along the dorsal-ventral axis, repress neural fates and control morphogenesis of the larva. Moreover, Nodal establishes left-right asymmetry by… CONTINUE READING
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