Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis.

@article{Coman2006NodalPA,
  title={Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis.},
  author={Ir{\`e}ne Coman and Marie St{\'e}phane Aigrot and Danielle Seilhean and Richard Reynolds and Jean Antoine Girault and Bernard Zalc and Catherine Lubetzki},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 12},
  pages={3186-95}
}
Saltatory conduction in myelinated fibres depends on the specific molecular organization of highly specialized axonal domains at the node of Ranvier, the paranodal and the juxtaparanodal regions. Voltage-gated sodium channels (Na(v)) have been shown to be deployed along the naked demyelinated axon in experimental models of CNS demyelination and in multiple sclerosis lesions. Little is known about aggregation of nodal, paranodal and juxtaparanodal constituents during the repair process. We… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…