Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

  title={Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island},
  author={J. Viala and C. Chaput and Ivo G Boneca and A. Cardona and Stephen E. Girardin and Anthony P. Moran and Rafika Athman and S. M{\'e}met and M. Huerre and Anthony J. Coyle and Peter S DiStefano and Philippe J Sansonetti and A. Labigne and John Bertin and Dana J Philpott and Richard L. Ferrero},
  journal={Nature Immunology},
  • J. Viala, C. Chaput, +13 authors Richard L. Ferrero
  • Published 2004
  • Biology, Medicine
  • Nature Immunology
  • Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells. We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan. Nod1 detection of H. pylori depended on the delivery of peptidoglycan to host cells by a bacterial type IV secretion system… CONTINUE READING
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