Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

@article{Viala2004Nod1RT,
  title={Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island},
  author={Jérôme Viala and Catherine Chaput and Ivo Gomperts Boneca and Ana Mar{\'i}a V{\'a}squez Cardona and Stephen E. Girardin and Anthony Patrick Moran and Rafika Athman and Sylvie M{\'e}met and Michel R Huerre and Anthony J Coyle and Peter S. Distefano and Philippe J. Sansonetti and Agnès Labigne and John Bertin and Dana J. Philpott and Richard L. Ferrero},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1166-1174}
}
Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells. We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan. Nod1 detection of H. pylori depended on the delivery of peptidoglycan to host cells by a bacterial type IV secretion system… Expand
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