Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.

@article{Park2007Nod1RICKAT,
  title={Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.},
  author={Jinhyang Park and Yun-Gi Kim and Michael H. Shaw and Thirumala-Devi Kanneganti and Yukari Fujimoto and Koichi Fukase and Naohiro Inohara and Gabriel N{\'u}{\~n}ez},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={
          514-21
        }
}
Mesothelial cells that line the serous cavities and outer surface of internal organs are involved in inflammatory responses induced by microbial stimuli and bacterial infection. Upon exposure to bacterial products, mesothelial cells secrete chemokines, but the signaling pathways by which these cells recognize bacteria to mediate innate immune responses remain largely unknown. We report that stimulation of primary peritoneal mesothelial cells via nucleotide-binding oligomerization domain (Nod)1… CONTINUE READING
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