Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.

@article{Unger2014NodlikeRX,
  title={Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.},
  author={Benjamin L. Unger and Shyamala Ganesan and Adam T. Comstock and Andrea N. Faris and Marc B Hershenson and Umadevi S Sajjan},
  journal={Journal of virology},
  year={2014},
  volume={88 7},
  pages={
          3705-18
        }
}
UNLABELLED Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen species (ROS) dependent, implying that dsRNA generated during RV replication is sufficient for disrupting barrier function. We also demonstrated that RV or poly(I·C)-stimulated NADPH… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES