Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome.

@article{Nakagawa2008NocturnalRI,
  title={Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome.},
  author={Yasuhiko Nakagawa and Ken Kishida and Shinji Kihara and Mina Sonoda and Ayumu Hirata and Atsutaka Yasui and Hitoshi Nishizawa and Tadashi Nakamura and Ryoko Yoshida and Iichiro Shimomura and Tohru Funahashi},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 4},
  pages={
          E778-84
        }
}
Previous reports demonstrated that adiponectin has antiatherosclerotic properties. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is reported to exacerbate atherosclerotic diseases. We investigated nocturnal alternation of serum adiponectin levels before sleep and after wake-up in OSAHS patients and the effect of sustained hypoxia on adiponectin in vivo and in vitro. We measured serum adiponectin concentrations in 75 OSAHS patients and 18 control subjects before sleep and after wake-up and… CONTINUE READING

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