Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia.

@article{Hasday1987NocturnalIO,
  title={Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia.},
  author={Jeffrey D Hasday and Cyril M. Grum},
  journal={The American review of respiratory disease},
  year={1987},
  volume={135 3},
  pages={
          534-8
        }
}
Sleep-associated hypoxemia may result in tissue hypoxia and increased production and excretion of adenosine triphosphate (ATP) degradation intermediates and uric acid. Urinary uric acid:creatinine(UA:Cr) ratio is a convenient method for estimating uric uric acid excretion. We measured the overnight changes in urinary UA:Cr ratio in 17 patients with documented sleep-associated hypoxemia, 13 control patients who remained normoxemic during polysomnography, and 14 normal volunteers. The urinary UA… CONTINUE READING

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