Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease.

  title={Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease.},
  author={Fenella Jane Kirkham and Deborah K M Hewes and Mara Prengler and Angela Wade and Roderick Lane and J. P. Evans},
  volume={357 9269},
BACKGROUND Central-nervous-system (CNS) events, including strokes, transient ischaemic attacks, and seizures are common in sickle-cell disease. Stroke can be predicted by high velocities in the internal-carotid or middle-cerebral arteries on transcranial doppler ultrasonography. We tested the hypothesis that nocturnal hypoxaemia can predict CNS events better than clinical or haematological features, or transcranial doppler sonography. METHODS We screened 95 hospital-based patients with sickle… CONTINUE READING


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