Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily.

@article{Hatlebakk1998NocturnalGA,
  title={Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily.},
  author={Jan Gunnar Hatlebakk and Philip O. Katz and B Kuo and D. Castell},
  journal={Alimentary pharmacology & therapeutics},
  year={1998},
  volume={12 12},
  pages={1235-40}
}
BACKGROUND On chronic intake of omeprazole, most healthy volunteers and patients still have nocturnal acid breakthrough (NAB), defined as night-time periods with gastric pH < 4.0 lasting for longer than 1 h. Gastro-oesophageal reflux during NAB may be particularly injurious to the oesophageal mucosa, contributing to the chronic lesions complicating the condition. AIM To compare the effect of three different dosing regimens of omeprazole 40 mg daily with regard to suppressing nocturnal gastric… CONTINUE READING
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