Nocodazole does not synchronize cells: implications for cell-cycle control and whole-culture synchronization

@article{Cooper2005NocodazoleDN,
  title={Nocodazole does not synchronize cells: implications for cell-cycle control and whole-culture synchronization},
  author={Stephen Cooper and Geetha Iyer and Michael Tarquini and Patrick G. Bissett},
  journal={Cell and Tissue Research},
  year={2005},
  volume={324},
  pages={237-242}
}
It has been predicted that nocodazole-inhibited cells are not synchronized because nocodazole-arrested cells with a G2-phase amount of DNA would not have a narrow cell-size range reflecting the cell size of some specific, presumably G2-phase, cell-cycle age. Size measurements of nocodazole-inhibited cells now fully confirm this prediction. Further, release from nocodazole inhibition does not produce cells that move through the cell cycle mimicking the passage of normal unperturbed cells through… CONTINUE READING

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