Nocistatin, a peptide that blocks nociceptin action in pain transmission

@article{OkudaAshitaka1998NocistatinAP,
  title={Nocistatin, a peptide that blocks nociceptin action in pain transmission},
  author={Emiko Okuda‐Ashitaka and Toshiaki Minami and Shinro Tachibana and Yoshihiro Yoshihara and Yuji Nishiuchi and Terutoshi Kimura and Seiji Ito},
  journal={Nature},
  year={1998},
  volume={392},
  pages={286-289}
}
Prolonged tissue damage or injury often leads to chronic pain states such that noxious stimuli evoke hyperalgesia and innocuous tactile stimuli evoke pain (allodynia),. The neuropeptide nociceptin,, also known as orphanin FQ (ref. 5), is an endogenous ligand for the orphan opioid-like receptor which induces both hyperalgesia and allodynia when administered by injection through the theca of the spinal cord into the subarachnoid space (that is, intrathecally),. Here we show that the nociceptin… 
Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-d-aspartate receptor GluRε subunit knockout mice
TLDR
Results demonstrate that capsaicin-sensitive primary afferent fibers are involved not only in thermal hyperalgesia but also in tactile allodynia induced by nociceptin, but in different pathways; the former is mediated by substance P and the latter ismediated by glutamate through the N-methyl-D-aspartate receptor comprising the GluRvarepsilon1 subunit.
Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice
TLDR
The effect of nocistatin amide was longer lasting and more potent, suggesting that the C-terminal free carboxyl group of nOCistatin is not necessary for its biological activity, and that the amide derivative may be more biologically stable.
Anti‐nociceptive responses produced by human putative counterpart of nocistatin
TLDR
It is demonstrated that h‐nocistatin is biologically active and may be involved in the processing of pain at the spinal level in humans.
Effect of nocistatin in pain modulation
TLDR
The results suggest that nocistatin can reverse the anti-morphine effect of OFQ in rat brain, but cannot inhibit the mechanical allodynia of neuropathic pain inRat brain and spinal cord.
Effect of supraspinal Nocistatin on Nociceptin/Orphanin FQ antagonism of selective opioid analgesia
TLDR
The data suggest that Nocistatin antagonizes the effect of Nociceptin on opioid analgesia and could play an important role in the regulation of nociceptive transmission.
Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
TLDR
Nocistatin is a novel bioactive peptide produced from the same precursor as Noc/OFQ, and it plays important roles in the regulation of pain transmission and learning and memory processes in the central nervous system.
Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice
TLDR
Results indicated that nocistatin, a new biologically active peptide, ameliorates impairments of spontaneous alternation and passive avoidance induced by scopolamine, and suggested that these peptides play opposite roles in learning and memory.
Effect of intrathecal nocistatin on nociceptin/orphanin FQ analgesia in chronic constriction injury rat
TLDR
N/OFQ dose-relatedly depressed thermal hyperalgesia produced by CCI and nocistatin could block N/OFq analgesia at spinal level in CCI rat, indicating that i.t. nocistsatin per se had no effect on the pain threshold of CCIRat, but could block the analgesic effect of N/ OFQ.
The Spinal Antinociceptive Effect of Nocistatin in Neuropathic Rats Is Blocked by D-Serine
TLDR
It is demonstrated that NST produces a biphasic dose-dependent effect on neuropathic pain and the spinal antinociception by NST is most likely attributable to inhibition of glycine-dependent N-methyl-d-aspartate receptor activation.
Central roles of nociceptin/orphanin FQ and nocistatin: allodynia as a model of neural plasticity.
TLDR
The multiple functions of Noc/OFQ and NST produced from the same precursor provide new insights into brain physiology, such as neural plasticity and may lead to therapeutic applications to the management of pain and neural disorders.
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References

SHOWING 1-10 OF 30 REFERENCES
Characterization of nociceptin hyperalgesia and allodynia in conscious mice
TLDR
The results demonstrate that, whereas the mechanisms of the nociceptin‐induced allodynia and hyperalgesia are evidently distinct, they involve a common neurochemical event beginning with the disinhibition of the inhibitory glycinergic response.
Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice
TLDR
NocII does not modify the number of explored holes in the hole board test, indicating that, unlike nociceptin, the orphan peptide does not affect exploratory behavior in mice.
Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses
  • Y. Taiwo, J. Levine
  • Medicine
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
TLDR
Prostaglandins can block endogenous opioid- mediated analgesia systems by inhibiting the bulbospinal noradrenergic component of this analgesia pathway, according to the findings of this study.
Characterization of EP‐receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice
TLDR
It is demonstrated that PGE2 may exert allodynia through the EP1‐receptor and hyperalgesia through EP2‐ and EP3‐receptors in the mouse spinal cord through use of 7 synthetic prostanoid analogues.
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
TLDR
Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.
Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus.
TLDR
The purification and characterization of a novel heptadecapeptide in bovine brain as an endogenous ligand for ROR-C, an opioid receptor homologue cloned from rat cerebrum demonstrate that the peptide exists in the brain and spinal cord and plays an important role in pain transmission.
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice
TLDR
The results demonstrate that the mechanism of PGE2&agr;‐induced allodynia is different from that of PGF2‐inducedAllodynia and from that from PGE 2‐agr ;‐induced hyperalgesia, which was not suppressed by taurine or clonidine.
Pharmacology of chronic pain.
TLDR
Current mechanistic aspects of chronic pain imposed by inflammation and peripheral neuropathy are focused on, and in particular the molecular changes involving the pharmacology of nociceptive pathways are reviewed since these have important implications for the management of pain.
Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
TLDR
Northern blot analysis shows that the PPNOC gene is predominantly transcribed in the central nervous system (brain and spinal cord) and, albeit weakly, in the ovary, the sole peripheral organ expressing the gene.
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
TLDR
Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
...
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