Heterogeneity in primary nociceptive neurons: From molecules to pathology
- BiologyArchives of pharmacal research
An extraordinary diversity among nociceptors likely reflects the evolutionary adaptation required to respond to an extremely variety of circumstances.
Nociceptors: a phylogenetic view
- BiologyJournal of Comparative Physiology A
This review will focus on what is known about nociceptors throughout the Animalia kingdom and what similarities exist across phyla; especially at the molecular level of ion channels.
Chapter 54 – Pain
TRPs and pain
- BiologySeminars in Immunopathology
This review focuses on the increasing evidence of TRP channel involvement and contribution in nociceptive pain and the pain hypersensitivity associated with peripheral inflammation or neuropathy, and on the renewed interest in targeting TRP channels for pain relief.
Comparative biology of pain: What invertebrates can tell us about how nociception works.
- BiologyJournal of neurophysiology
Invertebrates provide an opportunity to study nociception in an ethologically relevant context that can provide novel insights into the nature of how injury-inducing stimuli produce persistent changes in behavior.
TRP channels and pain.
- BiologyAnnual review of cell and developmental biology
Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli and is providing insight into the coding logic of nnociception and how specification of nOCiceptor subtypes underlies behavioral discrimination ofNoxious thermal, chemical, and mechanical stimuli.
Vagal afferent nerves with the properties of nociceptors
- BiologyAutonomic Neuroscience
Lifting the veil on the keratinocyte contribution to cutaneous nociception
- BiologyProtein & Cell
A review of recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions is highlighted.
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The high threshold mechanotransducer: A status report
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
Tackling Pain at the Source: New Ideas about Nociceptors
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
It is concluded that VR1 is required for inflammatory sensitization to noxious thermal stimuli but also that alternative mechanisms are sufficient for normal sensation of noxious heat.
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons
Aβ fibres appear to contribute to inflammatory hypersensitivity by switching their phenotype to one resembling pain fibres, thereby enhancing synaptic transmission in the spinal cord and exaggerating the central response to innocuous stimuli.
TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction
Spider toxins activate the capsaicin receptor to produce inflammatory pain
Venom from a tarantula that is native to the West Indies contains three inhibitor cysteine knot peptides that target the capsaicin receptor (TRPV1), an excitatory channel expressed by sensory neurons of the pain pathway, providing new tools for understanding mechanisms of TRP channel gating.
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
- BiologyJournal of neurophysiology
In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.