Nociceptor subpopulations involved in hyperalgesic priming.

  title={Nociceptor subpopulations involved in hyperalgesic priming.},
  author={Luiz F Ferrari and Oliver Bogen and Jon D Levine},
  volume={165 3},
We have previously developed a model in the rat for the transition from acute to chronic pain, hyperalgesic priming, in which a long-lasting neuroplastic change in signaling pathways mediates a prolongation of proinflammatory cytokine-induced nociceptor sensitization and mechanical hyperalgesia, induced at the site of a previous inflammatory insult. Induction of priming is mediated by activation of protein kinase C(epsilon) (PKC(epsilon)) in the peripheral terminal of the primary afferent… CONTINUE READING
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