Nociceptor-Enriched Genes Required for Normal Thermal Nociception.

  title={Nociceptor-Enriched Genes Required for Normal Thermal Nociception.},
  author={Ken Honjo and Stephanie E. Mauthner and Yu Wang and J. H. Pate Skene and W Daniel Tracey},
  journal={Cell reports},
  volume={16 2},
Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes. We then tested the function of the enriched genes with nociceptor-specific RNAi and thermal nociception assays. Tissue-specific RNAi targeted against 14 genes caused insensitive thermal nociception while targeting of 22 genes caused… CONTINUE READING
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