Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.

@article{Schicho2005NociceptiveTR,
  title={Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.},
  author={Rudolf Schicho and Josef Donnerer and Ingrid Liebmann and Irmgard Th. Lippe},
  journal={Brain research},
  year={2005},
  volume={1039 1-2},
  pages={108-15}
}
Little is known about transmitters that encode noxious gastric stimuli in the spinal cord. The release of glutamate, substance P, and CGRP from the spinal cord was therefore investigated in response to acid injury of the gastric mucosa. Dorsal halves of the caudal thoracic spinal cord (T7-T13) were removed 6 h after oral application of 0.5 M HCl or saline, transferred to a superfusion chamber, and the basal and capsaicin-stimulated (3.3 microM) transmitter release was determined. After acid… CONTINUE READING

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