Nociceptive and behavioural sensitisation by protein kinase Cɛ signalling in the CNS

@inproceedings{Kolen2007NociceptiveAB,
  title={Nociceptive and behavioural sensitisation by protein kinase Cɛ signalling in the CNS},
  author={Kristof Van Kolen and Shirley E Pullan and Jean-Marc Neefs and Frank Matthias Dautzenberg},
  year={2007}
}
Protein kinase C (PKC) (EC 2.7.11.13) (Enzyme Nomenclature 1992), represents a family of phospholipid-dependent serine/threonine phosphotransferases which are members of the protein kinase A (PKA), G and C superfamily. Most isoforms of PKC are activated in the presence of calcium (Ca) and diacylglycerol (DAG) (Nishizuka 1995). Once activated, these isozymes play central regulatory roles in a multitude of cellular processes, including proliferation, differentiation, tumourigenesis, cytoskeletal… CONTINUE READING
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