Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists

@article{Khan1998NociceptiveAA,
  title={Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists},
  author={Imran M. Khan and Hartmut Buerkle and Palmer Taylor and Tony L. Yaksh},
  journal={Neuropharmacology},
  year={1998},
  volume={37},
  pages={1515-1525}
}
  • Imran M. Khan, Hartmut Buerkle, +1 author Tony L. Yaksh
  • Published in Neuropharmacology 1998
  • Medicine, Chemistry
  • Activation of spinal nicotinic receptors evokes a prominent algogenic response. Recently, epibatidine, a potent nicotinic agonist, was found to display an antinociceptive response after systemic administration. To examine the spinal component of this action, effects of three nicotinic agonists epibatidine, cytisine and nicotine--were given intrathecally (IT) and their antinociceptive activity was subsequently assessed. All agents elicited dose-dependent algogenic activity, characterized at… CONTINUE READING

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