Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.

@article{Kashem2015NociceptiveSF,
  title={Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.},
  author={Sakeen W. Kashem and Maureen S. Riedl and Chen Yao and Christopher N Honda and Lucy Vulchanova and Daniel H Kaplan},
  journal={Immunity},
  year={2015},
  volume={43 3},
  pages={515-26}
}
Innate resistance to Candida albicans in mucosal tissues requires the production of interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism of cytokine production has not been precisely defined. In the skin, we found that dermal γδ T cells were the dominant source of IL-17A during C. albicans infection and were required for pathogen resistance. Induction of IL-17A from dermal γδ T cells and resistance to C. albicans required IL-23 production from CD301b… CONTINUE READING
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