Nociception and opioid-induced analgesia in lean (Fa/-) and obese (fa/fa) Zucker rats.

  title={Nociception and opioid-induced analgesia in lean (Fa/-) and obese (fa/fa) Zucker rats.},
  author={David S. Roane and Johnny R. Porter},
  journal={Physiology & behavior},
  volume={38 2},
Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick, p less than 0.05 and tail-pinch, p less than 0.001). Dose… CONTINUE READING

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