Nociceptin system as a target in sepsis?

@article{Thomas2014NociceptinSA,
  title={Nociceptin system as a target in sepsis?},
  author={Roisin C. Thomas and Cordula M Stover and David G Lambert and Jonathan P Thompson},
  journal={Journal of Anesthesia},
  year={2014},
  volume={28},
  pages={759-767}
}
The nociceptin system comprises the nociceptin receptor (NOP) and the ligand nociceptin/orphanin FQ (N/OFQ) that binds to the receptor. The archetypal role of the system is in pain processing but the NOP receptor is also expressed on immune cells. Activation of the NOP receptor is known to modulate inflammatory responses, such as mast-cell degranulation, neutrophil rolling, vasodilation, increased vascular permeability, adhesion molecule regulation and leucocyte recruitment. As there is a loss… 
Nociceptin/Orphanin FQ
Abstract Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide that is found in brain, immune, vascular endothelial and sertoli cells. It binds to and activates its cognate receptor, opioid
The endogenous nociceptin/orphanin FQ‐NOP receptor system as a potential therapeutic target for intestinal disorders
  • S. Agostini, C. Petrella
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
TLDR
Experimental and clinical studies focusing on the N/OFQergic system as pharmacological target for the therapeutic treatment of intestinal pathologies such as IBS and IBD are given.
Nociceptin/orphanin FQ antagonizes lipopolysaccharide‐stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells
TLDR
A novel role of the peptide nociceptin (N/OFQ), the endogenous ligand of the NOPr that counteracts cell migration, proliferation and increase in IL‐1&bgr; mRNA elicited by LPS via TLR4 in U87 glioblastoma cells is described.
N/OFQ-NOP System in Peripheral and Central Immunomodulation.
TLDR
Clinical ligands with wide central and peripheral distribution have the potential to modulate immune function, and defining the precise nature of that interaction is important in mitigating or even harnessing the adverse effect profile of these important drugs.
Sepsis and the orexin system
TLDR
The OXergic system plays an important role in several physiological functions such as feeding, sleep–wake cycle, locomotion, thermoregulation, autonomic function including cardiovascular function, and analgesia.
Nociceptin/Orphanin FQ system and animal models of sepsis
TLDR
The NOP receptor in rat spleen, functional coupling of splenocytes to MAP kinase, and expression in a rat model of sepsis is explored and the role of the nociceptin system in this study is investigated.
Neuroimmune Pathophysiology in Asthma
TLDR
The administration of experimental agents such as NK1R/NK2R antagonists and exogenous VIP decrease inflammatory mediators, suggesting that regulating the effects of NT/NP represents a potential novel approach for the treatment of asthma.
Influence of Orexinergic System on Survival in Septic Rats
TLDR
LPS significantly reduced OXA contents in the pons which contains the locus coeruleus to regulate sympathetic activity in the defense system and contributes to survival from sepsis in rats.
Modulation of Voltage-Gated Ca2+ Channels by G Protein-Coupled Receptors in Celiac-Mesenteric Ganglion Neurons of Septic Rats
TLDR
The findings suggest that CSMG function is affected by sepsis via changes in cell size and α2-adrenergic receptor-mediated Ca2+ channel modulation.
Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis
TLDR
It is demonstrated that the loss of TNAP enzyme activity in cerebral microvessels during late sepsis is coupled to sustained neuroimmune dysfunction which may underlie, in part, the chronic neurological impairments observed in septis survivors.
...
1
2
...

References

SHOWING 1-10 OF 67 REFERENCES
Nociceptin/orphanin FQ in inflammation and sepsis.
TLDR
There is a need for further observational and mechanistic studies in patients with established inflammatory processes or sepsis to facilitate the design of appropriate clinical studies to evaluate NOP ligands as modifiers of the inflammatory response.
The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo
TLDR
In inhibition of the microvascular N/OFQ-NOP pathway, the rat mesenteric microcirculation expresses NOP receptors and secondly, NOP function (ability to induce dilation) is enhanced with LPS.
NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases
TLDR
Human body fluid revealed increased levels of N/OFQ under sepsis, arthritis, and Parkinson's diagnose, and preclinical studies pointed to the blockade of NOP receptor signaling as successful in treating these experimental conditions.
Nociceptin receptor signaling in sympathetic neurons from septic rats.
TLDR
This study demonstrates the cecal ligation and puncture model-induced temporal upregulation of components within the NOP receptor signaling pathway in rat sympathetic neurons.
Expression of nociceptin/OFQ receptor and prepro-nociceptin/OFQ in lymphoid tissues
TLDR
It appears that nociceptin/orphanin FQ receptor mRNA, but not a functional receptor protein is expressed in the immune system.
Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation
TLDR
It is demonstrated that N/OFQ stimulates human monocyte chemotaxis via NOP receptor activation through the order of potency of agonists and the antagonist selectivity.
Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis
TLDR
Results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
Inflammatory Mediators Influence the Expression of Nociceptin and Its Receptor in Human Whole Blood Cultures
TLDR
LPS as well as cytokines suppress mainly NOP and, in part, PNoc mRNA expression in human whole blood cultures, which may represent a negative feedback loop to the previously described upregulation of cytokines by PNOC.
Expression of the nociceptin precursor and nociceptin receptor is modulated in cancer and septic patients.
TLDR
NOP and pN/OFQ expression in peripheral blood cells was modulated in end-stage cancer and septic patients compared with healthy controls, whereas changes in postoperative patients were minor, indicating the involvement of the NOP-pN-OFQ system in inflammation, impaired immune function, and pain.
Regulation of nociceptin/orphaninFQ secretion by immune cells and functional modulation of interleukin-2
TLDR
It is suggested that N/OFQ may promote anti-inflammatory actions via suppression of IL-2 in vivo and a variety of stimuli relevant to inflammation can regulate endogenous N/ OFQ secretion by splenocytes in vitro.
...
1
2
3
4
5
...