Nociceptin system as a target in sepsis?

@article{Thomas2014NociceptinSA,
  title={Nociceptin system as a target in sepsis?},
  author={R{\'o}is{\'i}n Thomas and Cordula M Stover and David G Lambert and Jonathan P Thompson},
  journal={Journal of Anesthesia},
  year={2014},
  volume={28},
  pages={759-767}
}
The nociceptin system comprises the nociceptin receptor (NOP) and the ligand nociceptin/orphanin FQ (N/OFQ) that binds to the receptor. The archetypal role of the system is in pain processing but the NOP receptor is also expressed on immune cells. Activation of the NOP receptor is known to modulate inflammatory responses, such as mast-cell degranulation, neutrophil rolling, vasodilation, increased vascular permeability, adhesion molecule regulation and leucocyte recruitment. As there is a loss… 
The endogenous nociceptin/orphanin FQ‐NOP receptor system as a potential therapeutic target for intestinal disorders
  • S. Agostini, C. Petrella
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
TLDR
Experimental and clinical studies focusing on the N/OFQergic system as pharmacological target for the therapeutic treatment of intestinal pathologies such as IBS and IBD are given.
N/OFQ-NOP System in Peripheral and Central Immunomodulation.
TLDR
Clinical ligands with wide central and peripheral distribution have the potential to modulate immune function, and defining the precise nature of that interaction is important in mitigating or even harnessing the adverse effect profile of these important drugs.
Sepsis and the orexin system
TLDR
The OXergic system plays an important role in several physiological functions such as feeding, sleep–wake cycle, locomotion, thermoregulation, autonomic function including cardiovascular function, and analgesia.
Nociceptin/Orphanin FQ system and animal models of sepsis
TLDR
The NOP receptor in rat spleen, functional coupling of splenocytes to MAP kinase, and expression in a rat model of sepsis is explored and the role of the nociceptin system in this study is investigated.
Neuroimmune Pathophysiology in Asthma
TLDR
The administration of experimental agents such as NK1R/NK2R antagonists and exogenous VIP decrease inflammatory mediators, suggesting that regulating the effects of NT/NP represents a potential novel approach for the treatment of asthma.
Influence of Orexinergic System on Survival in Septic Rats
TLDR
LPS significantly reduced OXA contents in the pons which contains the locus coeruleus to regulate sympathetic activity in the defense system and contributes to survival from sepsis in rats.
Modulation of Voltage-Gated Ca2+ Channels by G Protein-Coupled Receptors in Celiac-Mesenteric Ganglion Neurons of Septic Rats
TLDR
The findings suggest that CSMG function is affected by sepsis via changes in cell size and α2-adrenergic receptor-mediated Ca2+ channel modulation.
Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis
TLDR
It is demonstrated that the loss of TNAP enzyme activity in cerebral microvessels during late sepsis is coupled to sustained neuroimmune dysfunction which may underlie, in part, the chronic neurological impairments observed in septis survivors.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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