Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors


Nociceptin (or orphanin FQ), the endogenous ligand for the opioid receptor-like 1 (ORL1) receptor, decreases blood pressure in the conscious and anesthetized rat. This study examined whether prejunctional inhibitory ORL1 receptors located on the postganglionic sympathetic neurons innervating the resistance vessels are detectable in pithed rats. In pithed… (More)
DOI: 10.1007/s002109900160