Nociceptin attenuates opioid and gamma-aminobutyric acid(B) receptor-mediated analgesia in the mouse tail-flick assay.

@article{Citterio2000NociceptinAO,
  title={Nociceptin attenuates opioid and gamma-aminobutyric acid(B) receptor-mediated analgesia in the mouse tail-flick assay.},
  author={Francesca Citterio and Laura Corradini and Richard D. Smith and Rosalia Bertorelli},
  journal={Neuroscience letters},
  year={2000},
  volume={292 2},
  pages={
          83-6
        }
}
Nociceptin (NC) and the opioid receptor like-1 receptors are widely distributed in areas of the neuraxis that are part of the descending modulatory pain system. We used the tail-flick assay in mice to assess the interaction between NC and other analgesic compounds acting on different areas of the descending pathway. Given by intracerebroventricular injection, NC induced hyperalgesia at 10 nmol (39% of reduction vs. control group). The same dose of NC reversed analgesia induced by distinct… CONTINUE READING