Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect.

@article{Ciccocioppo2004NociceptinorphaninFA,
  title={Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect.},
  author={Roberto Ciccocioppo and Andrea Cippitelli and Daina Economidou and Amalia Fedeli and Maurizio Massi},
  journal={Physiology & behavior},
  year={2004},
  volume={82 1},
  pages={63-8}
}
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP opioid receptor (previously referred to as ORL1 or OP4 receptor), exerts a variety of behavioral effects. N/OFQ as well as the synthetic NOP receptor agonist Ro 64-6198 have been reported to possess antistress properties and to elicit a pronounced hyperphagic effect in freely feeding rats. These findings have raised our interest to investigate possible interactions in the control of ingestive behavior between N/OFQ and… CONTINUE READING

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