Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect

  title={Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect},
  author={Roberto Ciccocioppo and Andrea Cippitelli and Daina Economidou and Amalia Fedeli and Maurizio Massi},
  journal={Physiology \& Behavior},

Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis

Evaluating the role of the BST in the functional antagonism between N/OFQ and CRF by examining it at molecular level and in the context of CRF-induced anxiety in the rat suggests that this antagonism may occur within the BST.

The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications.

  • N. Zaveri
  • Biology, Psychology
    Current topics in medicinal chemistry
  • 2011
As with the case of buprenorphine, a mixed-action profile of NOP/opioid activity may provide a more effective drug to treat addiction to various abused substances and/or polydrug addiction.

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

The current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety.

A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder

These are the first data demonstrating that a systemically administered NOP receptor antagonist can reduce feeding behavior and body weight in rodents.

Interaction Between Nociceptin/Orphanin FQ and Adrenergic System on Food Intake in Neonatal Chicken

The results suggest that the effect of N/OFQ on cumulative food intake is mediated via β2 adrenergic receptors in neonatal chicken.

Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands

A rather unique behavioral profile since the activation or the blockade of a given neuropeptide receptor produces, in most of the cases, both antidepressant- and anxiolytic-like effects.

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats

The study indicates that both stress and anti-stress mechanisms are dysregulated in the extended AMY of msP rats and the voluntary alcohol drinking, as well as NOP agonism, have a significant impact on neuropeptidergic systems arrangement, bringing the systems back to normalization.



The Bed Nucleus Is a Neuroanatomical Substrate for the Anorectic Effect of Corticotropin-Releasing Factor and for Its Reversal by Nociceptin/Orphanin FQ

The ability of N/OFQ to prevent CRF-induced anorexia is investigated after microinjection studies into brain areas of potential interest in the control of feeding behavior and coexpressing NOP and CRF receptors, and it is demonstrated that the BNST is involved in the modulation of CRf-inducedanorexia.

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.

  • F. JenckJ. Moreau O. Civelli
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
It is shown that OFQ plays an important role in higher brain functions because it can act as an anxiolytic to attenuate the behavioral inhibition of animals acutely exposed to stressful/anxiogenic environmental conditions.

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

These data confirm the notable anxiolytic-like effects observed at low doses with the orphanin FQ/nociceptin neuropeptide given locally into the brain and support a role for orphan in F Q/nOCiceptin in adaptive behavioral fear responses to stress.

Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats

Findings provide original evidence that NC attenuates stress-induced anorexia, presumably by acting as a functional CRF antagonist, and suggest that the effect of NC is selective forAnorexia induced by stress or CRF.

Pharmacology of nociceptin and its receptor: a novel therapeutic target

New advances have contributed to better understanding of the pathophysiological role of the NC/OP4 system, and ultimately will help to identify the therapeutic potential of new OP4 receptor ligands.

Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats

It is reported that central injection of orphanin FQ induces feeding in satiated rats and that this effect can be blocked by peripheral administration of the opioid antagonist naloxone.

Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198

The results of this study show that the non-peptidic ORL1 receptor agonist Ro 64-6198 markedly and selectively inhibits the anorectic effect of stress and CRF, and provide evidence that this effect is mediated by OrL1 receptors.

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.

Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist

The findings suggest that [F/G)]NC(1–13)NH2, which has been reported to act as a NC receptor antagonist in peripheral tissues, be- haves as a full agonist at the central NC receptors controlling feeding, to study the physiological and pathophysiological role of NC in feeding behaviour.