Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.

@article{Ikeda2005NocardimicinsAB,
  title={Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.},
  author={Y. Ikeda and H. Nonaka and T. Furumai and H. Onaka and Y. Igarashi},
  journal={Journal of natural products},
  year={2005},
  volume={68 7},
  pages={
          1061-5
        }
}
  • Y. Ikeda, H. Nonaka, +2 authors Y. Igarashi
  • Published 2005
  • Chemistry, Medicine
  • Journal of natural products
  • In the screening for muscarinic M3 receptor binding inhibitors from microbial secondary metabolites, the extract of Nocardia sp. TP-A0674 was found to be highly active. Bioassay-guided fractionation of it led to the isolation of six new siderophores, nocardimicins A (1), B (2), C (3), D (4), E (5), and F (6), as active principles. Their chemical structures were determined by spectroscopic and degradation analysis. Of these congeners, nocardimicin B (2) inhibited the binding of tritium-labeled N… CONTINUE READING
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