Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways.

@article{Lien2016NobiletinAP,
  title={Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways.},
  author={L M Lien and Meng-Jiy Wang and Ray-Jade Chen and Hou-Chang Chiu and Jia-Lun Wu and M N Shen and Duen-Suey Chou and Joen-Rong Sheu and Kuan-Hung Lin and Wan-Jung Lu},
  journal={Phytotherapy research : PTR},
  year={2016},
  volume={30 2},
  pages={214-21}
}
Nobiletin, a bioactive polymethoxylated flavone (5,6,7,8,3(') ,4(') -hexamethoxyflavone), is abundant in citrus fruit peel. Although nobiletin exhibits antitumor activity against various cancer cells, the effect of nobiletin on glioma cells remains unclear. The aim of this study was to determine the effects of nobiletin on the human U87 and Hs683 glioma cell lines. Treating glioma cells with nobiletin (20-100 µm) reduced cell viability and arrested the cell cycle in the G0/G1 phase, as detected… CONTINUE READING