NoRC-dependent nucleosome positioning silences rRNA genes.

  title={NoRC-dependent nucleosome positioning silences rRNA genes.},
  author={Junwei Li and Gernot L{\"a}ngst and Ingrid Grummt},
  journal={The EMBO journal},
  volume={25 24},
Previous studies have established that the Snf2h-containing chromatin remodeling complex NoRC mediates epigenetic silencing of a subset of rRNA genes (rDNA) by recruiting enzymatic activities that modify histones and methylate DNA. Here we have analyzed nucleosome positions at the murine rDNA promoter and show that active and silent rDNA copies are characterized not only by specific epigenetic marks but also by differently positioned nucleosomes. At active genes the promoter-bound nucleosome… CONTINUE READING


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