NoFold: RNA structure clustering without folding or alignment.

  title={NoFold: RNA structure clustering without folding or alignment.},
  author={Sarah A Middleton and Junhyong Kim},
  volume={20 11},
Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function-for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated transcripts may therefore yield significant insight into their binding partners and mechanism of regulation. However, as most methods for clustering structures are based on folding individual sequences or… CONTINUE READING
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