No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer.

  title={No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer.},
  author={Amanda B Spurdle and Penelope M Webb and David M. Purdie and Xiao-qing Chen and A Richard Green and Georgia Chenevix-Trench},
  volume={22 5},
Epidemiological studies suggest that ovarian cancer is an endocrine-related tumour, and progesterone exposure specifically may decrease the risk of ovarian cancer. To assess whether the progesterone receptor (PR) exon 4 valine to leucine amino acid variant is associated with specific tumour characteristics or with overall risk of ovarian cancer, we examined 551 cases of epithelial ovarian cancer and 298 unaffected controls for the underlying G-->T nucleotide substitution polymorphism… CONTINUE READING


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