No significance of the COMT val158met polymorphism in restless legs syndrome.

Abstract

The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson's disease as well as with various chronic painful diseases… (More)
DOI: 10.1016/j.neulet.2010.02.042

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